Kyle was a founding leader of the University of California, Berkeley Global Science Institute (BGSI) where he was responsible for designing, implementing, and managing all global science centers in the United States and abroad (Japan, South Korea, Saudi Arabia, United Arab Emirates, Kuwait, Jordan, China, Malaysia, Indonesia, Argentina, and Mexico). His research focuses on further developing and promoting the principles of reticular chemistry for applications in clean energy, health, and the environment. He has co-authored more than 50 publications, including 6 in Science or Nature family journals, with >18,000 citations. Kyle has received awards including Leaders in Innovation Fellow from the UK Royal Academy of Engineering, IUPAC U.S. Young Observer from the US National Academies of Sciences, Engineering, and Medicine, Ronald E. McNair Scholar, and US National Cancer Institute CURE Scholar.