Sepo has research interests are in transdisciplinary fields as well as Africa’s science, technology and innovation policy landscape.

He has played a significant role in developing open science and systems analysis expertise aimed at addressing current global challenges through various programmes, including the Southern African Systems Analysis Centre, a multi-year initiative that supports systems analysis interventions in Africa, and the Africa Open Science Platform - a pan-Africa initiative which aims to position African scientists at the cutting edge of data-intensive science. He has been instrumental in spearheading Africa’s participation in regional and international bodies, including the Science Granting Council Initiative, the International Science Council and the International Institute for Applied Systems Analysis.

Sepo has published widely and authored, co-authored and edited more than 60 articles and books.  He has extensive networks on the continent and globally. His expertise includes stakeholder engagement with the public and private sectors: networking, cultivating and nurturing strategic partnerships across the continent, globe and sectors.

Sepo holds a master’s and doctoral degree in Environmental Science from the University of Cape Town.